反应详情

To 11 g (0.055 mole) of p-N,N-dimethylsulfamylaniline is added 17.68 ml (0.055) of 3.1 N hydrochloric acid. This is heated on a steam bath with 15 ml of isopropanol and 6.94 g (0.055 mole) of 1-i-propyl-3-cyanoguanidine. The reaction mixture is heated for 18 hours. The alcohol is evaporated off and diluted with 250 ml of 7.4% hydrochloric acid. The mixture is filtered, cooled and made alkaline with 10% sodium hydroxide. The precipitate is filtered, triturated with 100 ml of boiling isopropanol and filtered to get 1-(p-N,N-dimethylsulfamylphenyl)-5-i-propylbiguanide.

1. temperatureThe reaction mixture is heated for 18 hours
2. customThe alcohol is evaporated off
3. additiondiluted with 250 ml of 7.4% hydrochloric acid
4. filtrationThe mixture is filtered
5. temperaturecooled
6. filtrationThe precipitate is filtered
7. customtriturated with 100 ml of boiling isopropanol
8. filtrationfiltered