反应详情

To 20 g (0.1 mole) of 2,4,6-trichloroaniline and 12.6 g (0.1 mole) of 1-methyl-3-cyanoguanidine in 10 ml (0.1 mole) of concentrated hydrochloric acid is added 125 ml of n-butanol. The reaction mixture is refluxed for 17 hours, cooled and the alcohol evaporated off. The residue is extracted with ether after making it alkaline with 40% sodium hydroxide. The ether extract is dried over potassium carbonate and evaporated. The residue is dissolved in methanol, the pH adjusted to about 7, charcoal filtered and evaporated. The residue is triturated with ether and the solid that forms is recrystallized from water to obtain 1-(2,4,6-trichlorophenyl)-5-methylbiguanide hydrochloride.

1. temperatureThe reaction mixture is refluxed for 17 hours
2. temperaturecooled
3. customthe alcohol evaporated off
4. extractionThe residue is extracted with ether
5. extractionThe ether extract
6. dry with materialis dried over potassium carbonate
7. customevaporated
8. dissolutionThe residue is dissolved in methanol
9. filtrationfiltered
10. customevaporated
11. customThe residue is triturated with ether
12. customthe solid that forms is recrystallized from water