Hydrochloric Acid → Phenethylamine, alpha,alpha-dimethyl-4-dimethylamino-, dihydrochloride

HRID 1973281Notes

Reaction equation

HRID 1973281 reaction equation
[CH3:1][C:2]([NH:14]C(=O)C)([CH3:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH3:12])[CH3:11])=[CH:6][CH:5]=1.[ClH:18]>O>[ClH:18].[ClH:18].[CH3:12][N:10]([CH3:11])[C:7]1[CH:8]=[CH:9][C:4]([CH2:3][C:2]([NH2:14])([CH3:13])[CH3:1])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2743045Acetamide, N-[2-[4-(dimethylamino)phenyl]-1,1-dimethylethyl]-

Product 1

HCID 3043619Phenethylamine, alpha,alpha-dimethyl-4-dimethylamino-, dihydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3.5 of N-[α, α-dimethyl-β-(4-dimethylaminophenyl) ethyl]acetamide in a mixture of 25 ml of water and 25 ml of concentrated hydrochloric acid is reluxed for 16 hours. The solution is then evaporated under reduced pressure and the residue is recrystallized twice from methanol isopropyl ether. Yield: 1.1 g, m.p. 239,5°-240,5°.

Workup

  1. customThe solution is then evaporated under reduced pressure
  2. customthe residue is recrystallized twice from methanol isopropyl ether

Sources & evidence

ORD record
ord-b1f78afda1d940c9a3edc7cd831de829
Source dataset
uspto-grants-1976_12
Patent number
US03996381

Reaction notes

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