2-Bromoethanol → HCID 86734254, compound

HRID 1973374Notes

Reaction equation

HRID 1973374 reaction equation
[O:1]=[C:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[C:12]([O:14][CH2:15][CH3:16])=[O:13].Br[CH2:18][CH2:19][OH:20].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[OH:20][CH2:19][CH2:18][N:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:2]1=[O:1]

Participants

5

Reactant 3

HCID 108982-BromoethanolHCID 11430Potassium CarbonateHCID 248643Ethyl 3-hydroxyquinoxaline-2-carboxylate

Product 1

HCID 86734254HCID 86734254, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

3,4-Dihydro-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester (1 g), 2-bromoethanol (1.15 g) and anhydrous potassium carbonate (3 g) were heated under reflux in butanone (100 ml) for 5 hours. The mixture was cooled and the solid was filtered off. The filtrate was evaporated to give an oil which was crystallised from a mixture of benzene and light petroleum (b.p. 60°-80°). It had m.p. 137°-138°.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthe solid was filtered off
  3. customThe filtrate was evaporated
  4. customto give an oil which
  5. customwas crystallised from a mixture of benzene and light petroleum (b.p. 60°-80°)

Sources & evidence

ORD record
ord-9a538f15c67d4855b30f3e9a2c0089fe
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

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