Hydrochloric Acid → HCID 178522732, compound

HRID 1973378Notes

Reaction equation

HRID 1973378 reaction equation
C([O:3][CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([C:16]([NH:18][C:19]2[NH:23][N:22]=[N:21][N:20]=2)=[O:17])[C:7]1=[O:24])=O.[OH-].[Na+].Cl>O>[OH:3][CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([C:16]([NH:18][C:19]2[NH:23][N:22]=[N:21][N:20]=2)=[O:17])[C:7]1=[O:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178525588HCID 178525588, compound

Product 1

HCID 178522732HCID 178522732, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4(2-Formyloxyethyl)-3,4-dihydro-3-oxo-N(1H-tetrazol-5-yl)-2-quinoxalinecarboxamide (Example 20d) (1.85 g) in water (100 ml) was treated with sodium hydroxide (5.9 ml., 2N) and the solution was stirred for 30 minutes at room temperature. Hydrochloric acid (6 ml., 2N) was added and the solid was collected and crystallised from aqueous dimethylformamide and dried. It had m.p. 269° (d).

Workup

  1. customthe solid was collected
  2. customcrystallised from aqueous dimethylformamide
  3. customdried

Sources & evidence

ORD record
ord-f40c7e7964f04f8fabd5f980abf1544c
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

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