Methyl iodide → HCID 86734256, compound

HRID 1973382Notes

Reaction equation

HRID 1973382 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:7](=[O:18])[NH:6]2.CI.[C:21](=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:7](=[O:18])[N:6]2[CH3:21]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 22917218HCID 22917218, compound

Product 1

HCID 86734256HCID 86734256, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

3,4-Dihydro-6-methoxy-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester (1.9 g), methyl iodide (2 ml) and anhydrous potassium carbonate (6 g) in 2-butanone (100 ml) were stirred and heated under reflux for 1.5 hours. The solid was filtered off and the filtrate was evaporated. The residue was crystallised from aqueous methanol, m.p. 166° (80%).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 1.5 hours
  3. filtrationThe solid was filtered off
  4. customthe filtrate was evaporated
  5. customThe residue was crystallised from aqueous methanol, m.p. 166° (80%)

Sources & evidence

ORD record
ord-3d611fe40f674a7791b034bd340283e1
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

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