HCID 21491318, compound → HCID 178487978, compound

HRID 1973384Notes

Reaction equation

HRID 1973384 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([OH:15])=O)[C:7](=[O:16])[N:6]2[CH3:17].[NH2:18][C:19]1[NH:23][N:22]=[N:21][N:20]=1>O1CCCC1.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([NH:18][C:19]1[NH:23][N:22]=[N:21][N:20]=1)=[O:15])[C:7](=[O:16])[N:6]2[CH3:17]

Participants

5

Reactant 2

HCID 21491318HCID 21491318, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178487978HCID 178487978, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

3,4-Dihydro-6-methoxy-4-methyl-3-oxo-2-quinoxalinecarboxylic acid (1.2 g) and N,N'-carbonyldiimidazole (0.8 g) in tetrahydrofuran (25 ml) and dimethylformamide (20 ml) were heated under reflux for 1 hour. 5-Amino-1H-tetrazole (0.5 g) in dimethylformamide (5 ml) was added and the solution was heated under reflux for 1 hour and allowed to cool. The solid was collected and dried, m.p. 295°-296° (d) (70%).

Workup

  1. temperatureunder reflux for 1 hour
  2. temperaturethe solution was heated
  3. temperatureunder reflux for 1 hour
  4. temperatureto cool
  5. customThe solid was collected
  6. customdried

Sources & evidence

ORD record
ord-fec08da9eba24622b3128ebee8c74199
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

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