反应详情

Twenty parts 4-cyano-2,5-diisopropylbenzenesulfonamide is refluxed with 50 parts of potassium hydroxide and 400 parts of ethylene glycol under nitrogen for 24 hours. The cooled reaction mixture is diluted with 600 parts of water and acidified with hydrochloride acid. The precipitated product is filtered and washed with water. Drying gives 17 parts of 4-carboxy-2,5-diisopropylbenzenesulfonamide having a.m.p. of 225°-231°.

1. customThe cooled reaction mixture
2. filtrationThe precipitated product is filtered
3. washwashed with water
4. customDrying