反应详情

4-Carboxy-2,5-diisopropylbenzenesulfonamide, 60 parts in 250 parts of ether and 350 parts of tetrahydrofuran is added dropwise to 24 parts of lithium aluminum hydride in 500 parts of ether at a rate where the ether refluxes gently. The reactants are then refluxed for 16 hours. Dilute hydrochloric acid is then added dropwise until the inorganic salts precipitate. The mixture is filtered and dried over sodium sulfate. After filtration and solvent removal there remains 41 parts of 4-hydroxymethyl-2,5-diisopropylbenzenesulfonamide having a m.p. of 185°-189°.

1. temperatureThe reactants are then refluxed for 16 hours
2. filtrationThe mixture is filtered
3. dry with materialdried over sodium sulfate
4. filtrationAfter filtration and solvent removal