Hydrogen Bromide → HCID 21492138, compound

HRID 1973546Notes

Reaction equation

HRID 1973546 reaction equation
O[CH2:2][C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([S:12]([NH2:15])(=[O:14])=[O:13])=[C:5]([CH:16]([CH3:18])[CH3:17])[CH:4]=1.[BrH:19]>C(Cl)(Cl)Cl>[Br:19][CH2:2][C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([S:12]([NH2:15])(=[O:14])=[O:13])=[C:5]([CH:16]([CH3:18])[CH3:17])[CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 21492120HCID 21492120, compound

Product 1

HCID 21492138HCID 21492138, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 26 parts 4-hydroxymethyl-2,5-diisopropylbenzenesulfonamide dissolved in 100 parts chloroform heated just below reflux is added hydrogen bromide in a slow stream for an hour. The organic phase is washed with aqueous sodium bicarbonate, dried over magnesium sulfate and concentrated in vacuo to give 4-bromomethyl-2,5-diisopropylbenzenesulfonamide.

Workup

  1. temperatureheated just
  2. temperaturebelow reflux
  3. washThe organic phase is washed with aqueous sodium bicarbonate
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b5562b82999f4030bf6f6a2164abaa3c
Source dataset
uspto-grants-1976_12
Patent number
US03997603

Reaction notes

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