反应详情

The starting material can be obtained according to the procedure of A. R. Todd and F. Bergel, J. Chem. Soc. 1937, 365 by reaction of p-n-butoxybenzamidine hydrochloride with α-ethoxymethylene-α-cyanoacetic acid ethyl ester and sodium ethylate in ethanol and then with sodium hydroxide solution. The resulting 5-cyano-4-hydroxy-2-(4-n-butyoxyphenyl)-pyrimidine (melting point 223.2°-229.5° C) is treated with phosphorus oxychloride to give 4-chloro-5-cyano-2-(4-n-butoxyphenyl)-pyrimidine having a melting point of 169.7°-170.2° C.

1. customThe starting material can be obtained