huagongshe.com
HRID1973716

反应详情

EQUATION

反应方程式

HRID 1973716 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)c1ccccn1
HCID17307

Ethyl pyridine-2-carboxylate

C8H9NO2

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC5CCCCO5)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID131710577

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H](OC3CCCCO3)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)CCc4ccccn4)[C@@]3(C)CC(=O)[C@@H]12
HCID131710576

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Ethyl picolinate (1.0 ml.) was added to a mixture of 3α-(tetrahydropyran-2ξ-yloxy)-5α-pregnane-11,20-dione (840 mg) and sodium hydride (130 mg.) in dry dimethyl sulphoxide (15 ml.). The mixture was stirred, under N2, for 1/2 hr., then treated with methanol and poured into 2N-hydrochloric acid. The precipitate was collected, washed and dried to give 21-picolinyl-3α-(tetrahydropyran-2ξ-yloxy)-5α-pregnane-11,20-dione (695 mg.).

WORKUP

后处理

  1. customThe precipitate was collected
  2. washwashed
  3. customdried