Diethylamine → HCID 86734303, compound

HRID 1973733Notes

Reaction equation

HRID 1973733 reaction equation
[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH:13]([CH2:15][O:16][C:17](=[O:19])[CH3:18])I)[CH2:3]1.[CH2:31]([NH:33][CH2:34][CH3:35])[CH3:32]>ClCCl>[CH2:31]([N:33]([CH2:18][C:17]([O:16][CH2:15][CH2:13][C:12](=[O:20])[C@@H:11]1[C@:21]2([CH3:30])[C@H:8]([C@H:7]3[C@H:24]([C:23](=[O:29])[CH2:22]2)[C@:25]2([CH3:28])[C@H:4]([CH2:3][C@H:2]([OH:1])[CH2:27][CH2:26]2)[CH2:5][CH2:6]3)[CH2:9][CH2:10]1)=[O:19])[CH2:34][CH3:35])[CH3:32]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86734304HCID 86734304, compound

Product 1

HCID 86734303HCID 86734303, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3α-hydroxy-21-iodo-acetoxymethyl-5α-pregnane-11,20-dione (235 mg) in dry dichloromethane (25 ml) was treated with diethylamine (1 ml) in similar manner to that described in Example 35 to give title compound (89 mg)[αD ] + 73° (c 0.42).

Sources & evidence

ORD record
ord-6f7704490fdf4e88832e74bfe3e218b2
Source dataset
uspto-grants-1976_12
Patent number
US03998829

Reaction notes

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