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HRID1973741

反应详情

EQUATION

反应方程式

HRID 1973741 的结构方程式

REACTANTS

反应物

4
结构：CO
HCID887

Methanol

CH4O

结构：CCOC=O
HCID8025

Ethyl formate

C3H6O2

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC5CCCCO5)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID131710577

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H](OC3CCCCO3)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)CC=O)[C@@]3(C)CC(=O)[C@@H]12
HCID131710578

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Ethyl formate (0.7 ml) was added to a mixture of 3α-(tetrahydropyran-2ξ-yloxy)-5α-pregnane-11,20-dione (840 mg) and sodium hydride (130 mg) in dry dimethyl sulphoxide (15 ml). The mixture was stirred, under nitrogen for 11/4 hrs., then treated with methyl alcohol to destroy excess sodium hydride, and poured into dilute hydrochloric acid. The precipitate was collected, washed and dried to give title compound (943 mg).

WORKUP

后处理

  1. customto destroy excess sodium hydride
  2. additionpoured into dilute hydrochloric acid
  3. customThe precipitate was collected
  4. washwashed
  5. customdried