反应详情

A mixture of 33.35 parts of (2-bromoethyl)benzene, 35 parts of 4-[N-(4-methylphenyl)amino]-4-piperidinecarboxamide, 20 parts of N,N-diethylethanamine and 225 parts of N,N-dimethylacetamide is stirred for 4 hours at 70°-80° C. The reaction mixture is poured onto water and the product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated. The oily residue is poured onto water, whereupon the product is precipitated. It is filtered off and suspended twice in water. The product is filtered off again, washed with 2,2'-oxybispropane and dried, yielding 4-[N-(4-methylphenyl)amino]-1-(2-phenylethyl)-4-piperidinecarboxamide; mp. 163.1° C.

1. additionThe reaction mixture is poured onto water
2. extractionthe product is extracted with trichloromethane
3. washThe extract is washed with water
4. customdried
5. filtrationfiltered
6. customevaporated
7. additionThe oily residue is poured onto water, whereupon the product
8. customis precipitated
9. filtrationIt is filtered off
10. filtrationThe product is filtered off again
11. washwashed with 2,2'-oxybispropane
12. customdried