反应详情

A mixture of 3 parts of 4-(methoxymethyl)-N-phenyl-1-(2-phenylethyl)-4-piperidinamine and 5 parts of butanoic acid, anhydride is stirred and refluxed for 8 hours. The reaction mixture is poured onto water and the whole is alkalized with ammonium hydroxide. The product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated. The oily residue is stirred in 1,1'-oxybisethane with activated charcoal. The latter is filtered off and the filtrate is evaporated. The residue is converted into the ethanedioate salt 2-propanol. The salt is filtered off and crystallized from 2-propanone, yielding 1.7 parts of N-[4-(methoxymethyl)-1-(2-phenylethyl)-4-piperidinyl]-N-phenylbutanamide ethanedioate; mp. 174.2° C.

1. temperaturerefluxed for 8 hours
2. additionThe reaction mixture is poured onto water
3. extractionThe product is extracted with trichloromethane
4. washThe extract is washed with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. stirringThe oily residue is stirred in 1,1'-oxybisethane with activated charcoal
9. filtrationThe latter is filtered off
10. customthe filtrate is evaporated
11. filtrationThe salt is filtered off
12. customcrystallized from 2-propanone