Acetone → HCID 21490924, compound

HRID 1973901Notes

Reaction equation

HRID 1973901 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([CH2:11][CH2:12][CH2:13][CH3:14])=[CH:5][N:4]=1.[ClH:15].CC(C)=O>CO.CCOCC>[ClH:15].[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([CH2:11][CH2:12][CH2:13][CH3:14])=[CH:5][N:4]=1

Participants

6

Reactant 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 13154061(5-Butyl-4-methoxypyridin-2-yl)methanol

Product 1

HCID 21490924HCID 21490924, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of 2-hydroxymethyl-4-methoxy-5-n-butyl-pyridine in methanol is adjusted to pH 1 with hydrochloric acid in ether and evaporated to dryness. The water which still adheres is distilled off azeotropically with toluene. The residue thus obtained is digested with acetone and the crystalline product is filtered off. 2-Hydroxymethyl-4-methoxy-5-n-butyl-pyridine hydrochloride of melting point 136°-137° is thus obtained.

Workup

  1. customevaporated to dryness
  2. distillationThe water which still adheres is distilled off azeotropically with toluene
  3. customThe residue thus obtained
  4. filtrationthe crystalline product is filtered off

Sources & evidence

ORD record
ord-aeed5e8fff4941e58bb877b6c0ed57ff
Source dataset
uspto-grants-1976_12
Patent number
US03998955

Reaction notes

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