Ethyl orthoformate → [1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-5-phenyl-

HRID 1974079Notes

Reaction equation

HRID 1974079 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][NH2:13])[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH:20](OCC)(OCC)OCC>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:20]=[N:13][N:12]=[C:7]1[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 31214Ethyl orthoformateHCID 126119386-Chloro-2-hydrazinyl-4-phenylquinoline

Product 1

HCID 12246499[1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-5-phenyl-

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 2, 6-chloro-4-phenyl-2-hydrazinoquinoline and triethyl orthoformate are refluxed in xylene to give 7-chloro-5-phenyl-s-triazolo[4,3-a]quinoline of melting point 265°-266.5° C.

Sources & evidence

ORD record
ord-7a82c094e19a4816bc8405ccd17b37a6
Source dataset
uspto-grants-1976_12
Patent number
US04000151

Reaction notes

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