HRID1974317

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NC(=O)c1cc(C(=O)CN(Cc2ccccc2)Cc2ccccc2)ccc1O

HCID121727

5-((Bis(benzyl)amino)acetyl)salicylamide

C23H22N2O3

HCID170488

2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-

C9H17ClO2

HCID5360545

Sodium

PRODUCTS

生成物

结构：NC(=O)c1cc(C(=O)CN(Cc2ccccc2)Cc2ccccc2)ccc1OCCCCOC1CCCCO1

HCID21488956

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

A mixture of 5-(N,N-dibenzylglycyl)salicylamide, sodium salt (3.96 g), 2-(4-chlorobutoxy)tetrahydropyran (1.92 g) sodium iodide (1.40 g) and butanone (100 ml) was heated under reflux for 30 hours and filtered. The filtrate was evaporated to give an oil which crystallised from isopropanol to afford the ether as colourless crystals (2.95 g), m.p. 118°-123°.

WORKUP

后处理

temperaturewas heated
temperatureunder reflux for 30 hours
filtrationfiltered
customThe filtrate was evaporated
customto give an oil which
customcrystallised from isopropanol
customto afford the ether as colourless crystals (2.95 g), m.p. 118°-123°

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d8644fe7c0a14aa78563ec3b8957f6ad
来源数据集: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04000193
来源说明: uspto-grants-1976_12

反应 SMILES

[CH2:1]([N:8]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:9][C:10]([C:12]1[CH:20]=[C:16]([C:17]([NH2:19])=[O:18])[C:15]([OH:21])=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na].Cl[CH2:31][CH2:32][CH2:33][CH2:34][O:35][CH:36]1[CH2:41][CH2:40][CH2:39][CH2:38][O:37]1>CC(=O)CC>[CH2:22]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][C:10]([C:12]1[CH:13]=[CH:14][C:15]([O:21][CH2:31][CH2:32][CH2:33][CH2:34][O:35][CH:36]2[CH2:41][CH2:40][CH2:39][CH2:38][O:37]2)=[C:16]([CH:20]=1)[C:17]([NH2:19])=[O:18])=[O:11])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1