Water → HCID 23692102, compound

HRID 1974467Notes

Reaction equation

HRID 1974467 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[N:8][C:9]([C:15]2[NH:16][C:17](=[O:24])[C:18]([CH:21]([CH3:23])[CH3:22])([CH3:20])[N:19]=2)=[C:10]([CH:14]=1)[C:11]([OH:13])=[O:12].C(=O)(O)[O-].[Na+:29].O>O1CCCC1>[O:3]1[CH2:4][CH2:5][O:1][CH:2]1[C:6]1[CH:7]=[N:8][C:9]([C:15]2[NH:16][C:17](=[O:24])[C:18]([CH:21]([CH3:22])[CH3:23])([CH3:20])[N:19]=2)=[C:10]([CH:14]=1)[C:11]([O-:13])=[O:12].[Na+:29]

Participants

5

Reactant 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 15672410HCID 15672410, compound

Product 1

HCID 23692102HCID 23692102, compoundYield 76.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(1,3-Dioxolan-2-yl)-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (0.507 g, 0.00152 mol), sodium bicarbonate (0.12 g, 0.00143 mol), water and tetrahydrofuran is heated at reflux temperature for 1 hour. Concentration in vacuo yields a solid which is triturated with ether to give the title compound as an orange solid (0.39 g, 72%), mp 209°-210° C., identified by IR and NMR spectral analyses.

Workup

  1. temperatureat reflux temperature for 1 hour
  2. concentrationConcentration in vacuo
  3. customyields a solid which
  4. customis triturated with ether

Sources & evidence

ORD record
ord-83eda3b176be4531874c613d81994af8
Source dataset
uspto-grants-1994_02
Patent number
US05283230

Reaction notes

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