Hydrochloric Acid → HCID 19101563, compound

HRID 1974490Notes

Reaction equation

HRID 1974490 reaction equation
C([O:4][CH2:5][CH2:6][N:7]1[C:16]2[C:11](=[CH:12][C:13]([N+:22]([O-:24])=[O:23])=[C:14]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)[CH:15]=2)[NH:10][C:9](=[O:25])[C:8]1=[O:26])(=O)C.[ClH:27]>>[ClH:27].[OH:4][CH2:5][CH2:6][N:7]1[C:16]2[C:11](=[CH:12][C:13]([N+:22]([O-:24])=[O:23])=[C:14]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)[CH:15]=2)[NH:10][C:9](=[O:25])[C:8]1=[O:26]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10570436HCID 10570436, compound

Product 1

HCID 19101563HCID 19101563, compound

Conditions

Temperature
100 °C

Procedure

In 5 ml of 4N-hydrochloric acid was dissolved 250 mg of 1-(2-acetoxyethyl)-7-(1-imidazolyl)-6-nitroquinoxaline-2,3-(1H,4H)-dione of Example 17-14 and the solution was stirred at 100° C. for 3 hours. The reaction mixture was concentrated, followed by addition of methanol, whereupon crystals separated out. The crystals were recovered by filtration to provide 200 mg of 1-(2-hydroxyethyl)-7-(1-imidazolyl)-6-nitroquinoxaline-2,3-(1H,4H)-dione hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionfollowed by addition of methanol, whereupon crystals
  3. customseparated out
  4. filtrationThe crystals were recovered by filtration

Sources & evidence

ORD record
ord-867fa34f45a04b2496e568de21cb659a
Source dataset
uspto-grants-1994_02
Patent number
US05283244

Reaction notes

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