Chloroacetone → HCID 57304731, compound

HRID 1974495Notes

Reaction equation

HRID 1974495 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH:23]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:20]([NH2:22])=[S:21])=[CH:15][CH:14]=1.Cl[CH2:31][C:32](=O)[CH3:33].C(=O)(O)[O-].[Na+]>O>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH:19]([CH:23]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:20]2[S:21][CH:31]=[C:32]([CH3:33])[N:22]=2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 6571ChloroacetoneHCID 516892Sodium BicarbonateHCID 19101772HCID 19101772, compound

Product 1

HCID 57304731HCID 57304731, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.5 g (0.0037 mol) of the compound from Example III and 5 ml of chloroacetone are heated with 10 ml of water at 100° C. in an oil bath for 30 minutes. The mixture is then neutralised with sodium bicarbonate solution and extracted with methylene chloride. After the extract has been dried with sodium sulphate, it is concentrated to dryness in vacuo, and the residue is recrystallised in diisopropyl ether.

Workup

  1. extractionextracted with methylene chloride
  2. dry with materialAfter the extract has been dried with sodium sulphate, it
  3. concentrationis concentrated to dryness in vacuo
  4. customthe residue is recrystallised in diisopropyl ether

Sources & evidence

ORD record
ord-5ddc428680624a45a26965fb9fdd7591
Source dataset
uspto-grants-1994_02
Patent number
US05283252

Reaction notes

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