Potassium Carbonate → 1,2-Dimethyloctahydropyrrolo[3,4-b]pyrrole

HRID 1975009Notes

Reaction equation

HRID 1975009 reaction equation
[CH3:1][N:2]1[CH:9]([CH3:10])[CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH:9]([CH3:10])[CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19100939HCID 19100939, compound

Product 1

HCID 150700261,2-Dimethyloctahydropyrrolo[3,4-b]pyrrole

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

7.25 g (34.2 mmol) of ethyl 2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

Workup

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-45610a293f3646f4a95840590d125a00
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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