反应详情

5-Nitro-8-acetamidoquinoline prepared as above, (15 g, 64.9 mmol) was dissolved in tetrahydrofuran (75 ml) and treated with 40% hydrochloric acid (300 ml). The mixture was held at 80° C. for 3.5 hours and then allowed to cool. Tetrahydrofuran was removed under reduced pressure and the residual liquid was treated with saturated sodium bicarbonate solution until a neutral solution was obtained. The precipitate was removed by filtration to give 5-nitro-8-aminoquinoline (10 g).

1. temperatureto cool
2. customTetrahydrofuran was removed under reduced pressure
3. additionthe residual liquid was treated with saturated sodium bicarbonate solution until a neutral solution
4. customwas obtained
5. customThe precipitate was removed by filtration