Acetylacetone → Balazipone

HRID 1975717Notes

Reaction equation

HRID 1975717 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O)#[N:2].[CH3:11][C:12](=[O:17])[CH2:13][C:14](=[O:16])[CH3:15].C([O-])(=O)C.[NH4+]>CC(O)C>[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[C:13]([C:12](=[O:17])[CH3:11])[C:14](=[O:16])[CH3:15])#[N:2]

Participants

5

Reactant 3

HCID 31261AcetylacetoneHCID 90670m-FormylbenzonitrileHCID 517165Ammonium Acetate

Product 1

HCID 179347Balazipone

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-cyanobenzaldehyde (2,62 g) was condensed with 2,4-pentanedione (3,0 g) in 2-propanol (10 ml) in the presence of ammonium acetate. Mp 63°-64° C., yield 1.27 g (30 %).

Sources & evidence

ORD record
ord-9ecb82694a13496885ac6a6e9c7b10dc
Source dataset
uspto-grants-1994_02
Patent number
US05288750

Reaction notes

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