Sodium → HCID 178524302, compound

HRID 1975829Notes

Reaction equation

HRID 1975829 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]=1.[Na].[C:12]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27]Br)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][S:1][C:2]1[NH:3][C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]=1)(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 5360545SodiumHCID 12506913HCID 12506913, compoundHCID 178527813HCID 178527813, compound

Product 1

HCID 178524302HCID 178524302, compound

Procedure

The synthesis of this compound proceeded in the same fashion as in Example 3 using 6.79 g (0.045 mol) of 2-mercapto-1H-imidazo[4,5-c]pyridine, 1.14 g (0.0495 g atom) of sodium and 13.09 g (0.045 mol) of 2-(bromomethyl)phenyl benzoate. Purification of the crude material (12.75 g) by HPLC gave a product which on recrystallization from ethyl acetate had a m.p. 129°-132° C.

Workup

  1. customThe synthesis of this compound
  2. customPurification of the crude material (12.75 g) by HPLC
  3. customgave a product which
  4. customon recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-8fd4caaedf3e4949a1cf76fb7658f23a
Source dataset
uspto-grants-1994_02
Patent number
US05288871

Reaction notes

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