Sodium → HCID 178524401, compound

HRID 1975831Notes

Reaction equation

HRID 1975831 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]=1.[Na].[C:12]([O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27]Br)=[CH:23][CH:22]=1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([O:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:27][S:1][C:2]2[NH:3][C:4]3[CH:9]=[CH:8][N:7]=[CH:6][C:5]=3[N:10]=2)=[CH:25][CH:26]=1)(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 5360545SodiumHCID 10517659HCID 10517659, compoundHCID 178527813HCID 178527813, compound

Product 1

HCID 178524401HCID 178524401, compoundYield 53.4%

Procedure

The synthesis of this compound proceeded in the same fashion as in Example 15 using 4.17 g (0.028 mol) of 2-mercapto-1H-imidazo[4,5-c]pyridine, 0.70 g (0.030 g atom) of sodium, and 8.04 g (0.028 mol) of 4-(bromomethyl)phenyl benzoate. The filtered precipitate (7.90 g) was recrystallized from methylene chloride to give 5.40 g of product, m.p. 171°-174° C.

Workup

  1. customThe synthesis of this compound
  2. customThe filtered precipitate (7.90 g) was recrystallized from methylene chloride

Sources & evidence

ORD record
ord-2206597e248c46bb8ff28b07e33edeb4
Source dataset
uspto-grants-1994_02
Patent number
US05288871

Reaction notes

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