HCID 21999979, compound → HCID 21999989, compound

HRID 1975910Notes

Reaction equation

HRID 1975910 reaction equation
[N:1]([O-])=O.[Na+].[C:5]([C:7]1[C:8]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:9]([C:13]([NH:15][NH2:16])=[O:14])[S:10][C:11]=1[CH3:12])#[N:6]>O.Cl>[C:5]([C:7]1[C:8]([S:17](=[O:18])(=[O:19])[NH2:20])=[C:9]([C:13]([N:15]=[N+:16]=[N-:1])=[O:14])[S:10][C:11]=1[CH3:12])#[N:6]

Participants

5

Reactant 2

HCID 21999979HCID 21999979, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 21999989HCID 21999989, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A solution of sodium nitrite (0.47 g) in 5 ml of water was added dropwise to a stirred solution of 4-cyano-2-hydrazinocarbonyl-5-methyl-thiophene-3-sulfonamide (1.6 g) in 38 ml of 1 M hydrochloric acid at 0° C. The resulting mixture was stirred for 30 min at 0° C. and then filtered. The filter cake was washed with water and dried in vacuum to give 1.35 g of the title compound; 1H-NMR (DMSO-d6), δ(ppm): 7.75 (br, 1H, NH2), 2.75 (s, 1H, CH3).

Workup

  1. filtrationfiltered
  2. washThe filter cake was washed with water
  3. customdried in vacuum

Sources & evidence

ORD record
ord-3071feaac15041c2a7b0189a0ac05809
Source dataset
uspto-grants-2001_05
Patent number
US06225310B1

Reaction notes

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