Methylamine → HCID 11449803, compound

HRID 1975955Notes

Reaction equation

HRID 1975955 reaction equation
C(O[C:4](=[O:19])[C:5]1[C:10]([Br:11])=[CH:9][N:8]=[C:7]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)[CH:6]=1)C.[CH3:20][NH2:21]>>[Br:11][C:10]1[C:5]([C:4]([NH:21][CH3:20])=[O:19])=[CH:6][C:7]([N:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]2)=[N:8][CH:9]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 11221145Ethyl 5-bromo-2-(4-methyl-1-piperazinyl)-4-pyridinecarboxylate

Product 1

HCID 11449803HCID 11449803, compoundYield 100%

Procedure

A solution of 1.45 g (5.8 mmol) 5-bromo-2-(4-methyl-piperazin-1-yl)-isonicotinic acid ethyl ester in 25 ml methylamin (33% in ethanol) was heated in a high pressure vessel at 85° for 12 h. Evaporation of the solvent afforded 1.81 g (100%) of the title compound as yellow crystals. M.p. 122-125° C.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-1b34ab7a223b4be987d88aadaead1210
Source dataset
uspto-grants-2001_05
Patent number
US06225316B1

Reaction notes

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