Dimethylformamide → HCID 22000155, compound

HRID 1975980Notes

Reaction equation

HRID 1975980 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[C:18](I)[CH:19]=4)[N:14]=[CH:13][N:12]=3)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C(N[CH2:25][CH3:26])C.[CH3:27][N:28]([CH3:31])[CH:29]=O>>[CH2:27]([N:28]([CH3:31])[CH2:29][C:25]#[C:26][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[N:14]=[CH:13][N:12]=[C:11]2[NH:10][C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][CH:2]=[CH:3]2)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 8021DiethylamineHCID 15521320HCID 15521320, compound

Product 1

HCID 22000155HCID 22000155, compound

Procedure

The title compound was synthesized according to the method of Example 2 using (1H-indol-5-yl)-(6-iodo-quinazolin-4-yl)-amine (200 mg, 0.517 mmol), N-Methyl-n-proparglylbenzylamine (246 mg, 1.596 mmol) and diethyl amine (189 gm, 2.59 mmol) in 2 mL, of dimethylformamide (DMF).

Sources & evidence

ORD record
ord-4324a47c0731427fbf15592097e75237
Source dataset
uspto-grants-2001_05
Patent number
US06225318B1

Reaction notes

Loading…