Diethylamine → HCID 54529003, compound

HRID 1975982Notes

Reaction equation

HRID 1975982 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]3[C:20]4[C:15](=[CH:16][C:17]([O:22][CH3:23])=[C:18](I)[CH:19]=4)[N:14]=[CH:13][N:12]=3)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1)#[CH:25].C(NCC)C>CN(C=O)C>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]3[C:20]4[C:15](=[CH:16][C:17]([O:22][CH3:23])=[C:18]([C:25]#[C:24][C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=5)[CH:19]=4)[N:14]=[CH:13][N:12]=3)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 137268EthynylpyridineHCID 15521323HCID 15521323, compound

Product 1

HCID 54529003HCID 54529003, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was synthesized according to the method of Example 2 using (1H-indol-5-yl)-(6-iodo-7-methoxy-quinazolin-4-yl)-amine (135 mg, 0.486 mmol), 2-ethynyl-pyridine (185 mg, 1.45 mmol) and diethylamine (605 mg, 8.27 mmol) in 2 mL., of DMF.

Sources & evidence

ORD record
ord-45e40492d964464bbbd81f0464a4b546
Source dataset
uspto-grants-2001_05
Patent number
US06225318B1

Reaction notes

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