1,1'-Carbonyldiimidazole → HCID 22721792, compound

HRID 1976003Notes

Reaction equation

HRID 1976003 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:22])[CH2:7][NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10].[C:23](N1C=CN=C1)(N1C=CN=C1)=[O:24].[N:35]1[CH:40]=[CH:39][C:38]([N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)=[CH:37][CH:36]=1>>[CH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[CH:21][C:12]=1[S:9]([NH:8][CH2:7][C:6]([NH:5][CH2:4][CH2:3][NH:2][C:23]([N:44]1[CH2:43][CH2:42][N:41]([C:38]2[CH:39]=[CH:40][N:35]=[CH:36][CH:37]=2)[CH2:46][CH2:45]1)=[O:24])=[O:22])(=[O:11])=[O:10]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 705171-(4-Pyridyl)piperazineHCID 22721905HCID 22721905, compound

Product 1

HCID 22721792HCID 22721792, compoundYield 10%

Procedure

Using an analogous procedure to that described in Example 3, N-(2-aminoethyl)-2-(2-naphthalenesulphonamido)acetamide hydrochloride salt, 1,1′-carbonyldiimidazole and 1-(4-pyridyl)piperazine were reacted to give 2-(2-naphthalenesulphonamido)-N-{2-[4-(4-pyridyl)piperazin-1-ylcarbonylamino]ethyl}acetamide in 10% yield;

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2861e9d7628c4fbe8a2660d4ea268066
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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