Dicyclohexylamine → HCID 178420471, compound

HRID 1976306Notes

Reaction equation

HRID 1976306 reaction equation
[CH:1]1([NH:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:14]([CH2:17][C:18]1([CH3:45])[CH2:23][CH2:22][C:21]2[C:24]([CH3:44])=[C:25]([S:32]([NH:35][C:36](=[NH:43])[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)(=[O:34])=[O:33])[C:26]3[CH2:27][CH2:28][CH2:29][CH2:30][C:31]=3[C:20]=2[O:19]1)([OH:16])=[O:15]>CCOC(C)=O>[CH:8]1([NH:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1.[C:14]([CH2:17][C:18]1([CH3:45])[CH2:23][CH2:22][C:21]2[C:24]([CH3:44])=[C:25]([S:32]([NH:35][C:36](=[NH:43])[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)(=[O:33])=[O:34])[C:26]3[CH2:27][CH2:28][CH2:29][CH2:30][C:31]=3[C:20]=2[O:19]1)([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 7582DicyclohexylamineHCID 178421531HCID 178421531, compound

Product 1

HCID 178420471HCID 178420471, compoundYield 85.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of dicyclohexylamine (0.22 g) in AcOEt (1 ml) was added to a solution of N-(2-carboxymethyl-3,4,7,8,9,10-hexahydro-2,5-dimethyl-2H-naphtho[2,1-e]pyran-6-sulfonyl)benzamidine (0.55 g) in AcOEt (4 ml) and the mixture was stirred at room temperature to give N-(2-carboxymethyl-3,4,7,8,9,10-hexahydro-2,5-dimethyl-2H-naphtho[2,1-e]pyran-6-sulfonyl)benzamidine dicyclohexylamine salt as a solid (0.66 g).

Sources & evidence

ORD record
ord-7b6e951f49d24f75a722ac46a833be29
Source dataset
uspto-grants-2001_05
Patent number
US06225480B1

Reaction notes

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