1-Bromo-3-chloropropane → HCID 22644706, compound

HRID 1976402Notes

Reaction equation

HRID 1976402 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH:4]([NH:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]#[C:21][CH3:22])=[CH:14][CH:13]=1)(=[O:11])=[O:10])[CH:5]([CH3:7])[CH3:6].Br[CH2:25][CH2:26][CH2:27][Cl:28]>>[CH3:1][O:2][C:3](=[O:23])[CH:4]([N:8]([S:9]([C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][C:20]#[C:21][CH3:22])=[CH:16][CH:17]=1)(=[O:11])=[O:10])[CH2:25][CH2:26][CH2:27][Cl:28])[CH:5]([CH3:7])[CH3:6]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 54394859HCID 54394859, compound

Product 1

HCID 22644706HCID 22644706, compoundYield 75%

Procedure

According to the procedure of Example 5, 1.00 g (2.95 mmol) 2-(4but-2-ynyloxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester and 0.88 mL (8.849 mmol) of 1-bromo-3-chloropropane provided 0.92 g of methyl2-[{[4-(2-butynyloxy)penyl]sulfonyl}(3-chloropropyl)amino]-3-methylbutanoate as a white solid. Electrospray Mass Spec 416.2 (M+H)+

Sources & evidence

ORD record
ord-01be94561fe24fa5aff3f19723026f4b
Source dataset
uspto-grants-2001_05
Patent number
US06225311B1

Reaction notes

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