Hydrochloric Acid → HCID 21304717, compound

HRID 1976490Notes

Reaction equation

HRID 1976490 reaction equation
[C:1]([O:4][CH2:5][C:6]#[C:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([N:19]2[CH2:24][CH2:23][S:22][C:21]([CH3:26])([CH3:25])[C@@H:20]2[C:27]([O:29]C(C)(C)C)=[O:28])(=[O:18])=[O:17])=[CH:12][CH:11]=1)(=[O:3])[CH3:2].Cl>ClCCl>[C:1]([O:4][CH2:5][C:6]#[C:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([N:19]2[CH2:24][CH2:23][S:22][C:21]([CH3:25])([CH3:26])[C@@H:20]2[C:27]([OH:29])=[O:28])(=[O:18])=[O:17])=[CH:12][CH:11]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21304725HCID 21304725, compound

Product 1

HCID 21304717HCID 21304717, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Through a solution of 0.250 g (0.503 mmol) of tert-butyl(3 S)4-[(4-{[4-(acetyloxy)-2-butynyl]oxy}phenyl)sulfonyl]-2,2-dimethyl-3-thiomorpholine carboxylate in 10 mL of dichloromethane was bubbled hydrogen chloride gas for 10 minutes. The reaction was then stoppered and let sit overnight at room temperature The solvent was evaporated to give 0.192 g of (3S)-4-[(4-([4-(acetyloxy)-2-butynyl]oxy)phenyl)sulfonyl]-2,2 dimethyl-3-thiomorpholine carboxylic acid as a colorless oil. Electrospray Mass Spec 440.1 (M−H)−

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-de598462835043a89b966bf4a8e66e58
Source dataset
uspto-grants-2001_05
Patent number
US06225311B1

Reaction notes

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