Methyl trifluoroacetate → HCID 10535860, compound

HRID 1976546Notes

Reaction equation

HRID 1976546 reaction equation
[NH2:1][CH:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].[F:8][C:9]([F:15])([F:14])[C:10](OC)=[O:11]>CO>[F:8][C:9]([F:15])([F:14])[C:10]([NH:1][CH:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7])=[O:11]

Participants

4

Reactant 2

HCID 9893Methyl trifluoroacetateHCID 104868053-Amino-pyrrolidin-2-one

Product 1

HCID 10535860HCID 10535860, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of Intermediate 2 (181 g), methyl trifluoroacetate (218 ml) and methanol (2.6 l) was stirred for 2 h. The solvent was then removed in vacuo to afford the title compound as a cream solid (355 g). Mass spec. MNH4+ (found) 214 MNH4+ (calculated) 214

Workup

  1. customThe solvent was then removed in vacuo

Sources & evidence

ORD record
ord-562212bbe1ae4a95a094ec7d441fbaf2
Source dataset
uspto-grants-2001_05
Patent number
US06228853B1

Reaction notes

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