Water → HCID 69842380, compound

HRID 1976549Notes

Reaction equation

HRID 1976549 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][C@@H:13]([NH:16]C(=O)C(F)(F)F)[C@@H:12]1[CH:23]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH:24]([CH3:26])[CH3:25])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].O>C(O)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][C@@H:13]([NH2:16])[C@@H:12]1[CH:23]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH:24]([CH3:25])[CH3:26])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 57298235HCID 57298235, compound

Product 1

HCID 69842380HCID 69842380, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Intermediate 6 (31 g), potassium carbonate (71 g), water (930 ml) and ethanol (930 ml) were warmed at 60° C. for 3 h. The ethanol was removed in vacuo and the aqueous residue extracted with ethyl acetate (3×300 ml). The combined extracts were washed with brine and dried (MgSO4) and concentrated in vacuo to give the title compound as a brown oil (17.5 g).

Workup

  1. customThe ethanol was removed in vacuo
  2. extractionthe aqueous residue extracted with ethyl acetate (3×300 ml)
  3. washThe combined extracts were washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cdd5e39dd1b546b3abcc85065c2271c8
Source dataset
uspto-grants-2001_05
Patent number
US06228853B1

Reaction notes

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