反应详情

温度

0 °C

To a solution of 2-[1-(3-tert-butoxycarbonylamino-propyl)piperidin-4-yl] benzonitrile (0.73 g, 2.1 mmol) in ethyl acetate (100 ml), cooled to 0° C. was added hydrogen chloride gas, bubbled vigorously for 5 minutes. The reaction mixture was stirred for 10 minutes at 0° C., purged with argon and concentrated. Flushing with ethyl acetate×2 and concentration gave 2-[1-(3-aminopropyl)-piperidin-4-yl]benzonitrile hydrochloride.

1. custombubbled vigorously for 5 minutes
2. custompurged with argon
3. concentrationconcentrated
4. customFlushing with ethyl acetate×2 and concentration