Oxalyl chloride → HCID 15458808, compound

HRID 1976721Notes

Reaction equation

HRID 1976721 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=2)[CH:4]=[CH:3]1.[C:14](Cl)(=[O:18])[C:15]([Cl:17])=[O:16]>C(OCC)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=2)[C:4]([C:14](=[O:18])[C:15]([Cl:17])=[O:16])=[CH:3]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 106073591-Methyl-6-nitro-1H-indole

Product 1

HCID 15458808HCID 15458808, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A stirred solution of 1-methyl-6-nitro-1H-indole in diethyl ether (Et2O) (5 mL) was cooled to 0° C., and treated with oxalyl chloride (0.15 mL, 1.7 mm). After stirring at room temperature overnight, solids were collected, washed with ether and dried to afford (255 mg, 96%) (1-methyl-6-nitro-1H-indol-3-yl)-oxo-acetyl chloride.

Workup

  1. customsolids were collected
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-f33481816f434e8099713c881010763f
Source dataset
uspto-grants-2001_05
Patent number
US06228877B1

Reaction notes

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