Hydrochloric Acid → 3-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid

HRID 1976885Notes

Reaction equation

HRID 1976885 reaction equation
C(NC(=O)C(C)=CC1C=C(OC)C(OC)=CC=1N)CC1C=CC=CC=1.C([O:28][C:29](=[O:44])[C:30]([CH3:43])=[CH:31][C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([O:40][CH3:41])=[CH:34][C:33]=1[NH2:42])C.[OH-].[Na+].Cl>O1CCCC1>[NH2:42][C:33]1[CH:34]=[C:35]([O:40][CH3:41])[C:36]([O:38][CH3:39])=[CH:37][C:32]=1[CH:31]=[C:30]([CH3:43])[C:29]([OH:44])=[O:28]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702131123-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl esterHCID 702148893-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid phenethyl amide

Product 1

HCID 702156293-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Into 10 ml of tetrahydrofuran (THF), 1.0 g of (E) 3-(2-amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted at 40° C. for 4 hours. After the completion of the reaction, the mixture was cooled with 10 ml of 1-N hydrochloric acid being added thereto, and the precipitated crystal was filtered out, whereby 0.85 g of the aimed compound was obtained (95%).

Workup

  1. customthe mixture was reacted at 40° C. for 4 hours
  2. customAfter the completion of the reaction
  3. additionadded
  4. filtrationthe precipitated crystal was filtered out

Sources & evidence

ORD record
ord-0948cfe293c54871877431ce8759fad7
Source dataset
uspto-grants-2001_05
Patent number
US06229020B1

Reaction notes

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