Hydrochloric Acid → 3-(2-Amino-benzo[d]phenyl)-2-methyl-2-propenoic acid

HRID 1976895Notes

Reaction equation

HRID 1976895 reaction equation
C(NC(=O)C(C)=CC1C=C(OC)C(OC)=CC=1N)CC1C=CC=CC=1.C([O:28][C:29](=[O:44])[C:30]([CH3:43])=[CH:31][C:32]1[CH:37]=[C:36]2[CH:38]=[CH:39][C:40]([NH2:42])=[CH:41][C:35]2=[CH:34][CH:33]=1)C.[OH-].[Na+].Cl>O1CCCC1>[NH2:42][C:40]1[CH:39]=[CH:38][C:36]2[C:35]([CH:41]=1)=[CH:34][CH:33]=[C:32]([CH:31]=[C:30]([CH3:43])[C:29]([OH:44])=[O:28])[CH:37]=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702148893-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid phenethyl amideHCID 702169223-(2-Amino-benzo[d]phenyl)-2-methyl-2-propenoic acid ethyl ester

Product 1

HCID 702145023-(2-Amino-benzo[d]phenyl)-2-methyl-2-propenoic acidYield 98%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Into 10 ml of tetrahydrofuran (THF), 0.65 g of (E) 3-(2-amino-benzo[d]phenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted for 4 hours at 40° C. After the completion of the reaction, the reaction liquid was cooled with 10 ml of a 1-N aqueous hydrochloric acid solution being added thereto, and the precipitated crystal was filtered out, whereby 0.57 g of the aimed compound was obtained (yield: 98%).

Workup

  1. customthe mixture was reacted for 4 hours at 40° C
  2. customAfter the completion of the reaction
  3. customthe reaction liquid
  4. additionbeing added
  5. filtrationthe precipitated crystal was filtered out

Sources & evidence

ORD record
ord-77bc3fd9a6e74e74aeacbfecba87f882
Source dataset
uspto-grants-2001_05
Patent number
US06229020B1

Reaction notes

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