反应详情

Into 10 ml of tetrahydrofuran (THF), 0.65 g of (E) 3-(2-amino-benzo[d]phenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted for 4 hours at 40° C. After the completion of the reaction, the reaction liquid was cooled with 10 ml of a 1-N aqueous hydrochloric acid solution being added thereto, and the precipitated crystal was filtered out, whereby 0.57 g of the aimed compound was obtained (yield: 98%).

1. customthe mixture was reacted for 4 hours at 40° C
2. customAfter the completion of the reaction
3. customthe reaction liquid
4. additionbeing added
5. filtrationthe precipitated crystal was filtered out