Hydrochloric Acid → HCID 70230946, compound

HRID 1976903Notes

Reaction equation

HRID 1976903 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([N:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[CH:11]=[C:12]([CH3:18])[C:13]([O:15]CC)=[O:14].[OH-].[Na+].Cl>O1CCCC1>[NH2:1][C:2]1[CH:7]=[C:6]([N:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[CH:11]=[C:12]([CH3:18])[C:13]([OH:15])=[O:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70216867HCID 70216867, compound

Product 1

HCID 70230946HCID 70230946, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

ethyl 3-(2-amino-4-dimethylaminophenyl)-2-methyl-2-propenate was dissolved in tetrahydrofuran (THF); and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted for 4 hours at 40° C. After the completion of the reaction was verified by TLC, the mixture was cooled with 1-N hydrochloric acid being added thereto, and the precipitated crystal was filtered out, whereby the aimed compound was obtained.

Workup

  1. customthe mixture was reacted for 4 hours at 40° C
  2. additionadded
  3. filtrationthe precipitated crystal was filtered out

Sources & evidence

ORD record
ord-c3f4113175de4c569417358a9ce5fb61
Source dataset
uspto-grants-2001_05
Patent number
US06229020B1

Reaction notes

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