Hydrochloric Acid → 3-Amino-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester hydrochloride

HRID 1976915Notes

Reaction equation

HRID 1976915 reaction equation
[CH2:1]([O:8][C:9]([C:11]1([N:19]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:17][CH:16]2[O:18][CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>C(OCC)C>[ClH:33].[CH2:1]([O:8][C:9]([C:11]1([NH2:19])[CH2:17][CH:16]2[O:18][CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 540516143-(Benzhydrylideneamino)-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester

Product 1

HCID 699219873-Amino-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A two-phase mixture of 3-(benzhydrylideneamino)-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester (3.9 mmole) in aqueous 1N hydrochloric acid solution (100 mL) and diethyl ether (100 mL) is stirred at room temperature overnight. The aqueous layer is concentrated to provide the title compound.

Workup

  1. concentrationThe aqueous layer is concentrated

Sources & evidence

ORD record
ord-08b2206697d84ed8a2fdf522402b0b72
Source dataset
uspto-grants-2001_05
Patent number
US06229025B1

Reaction notes

Loading…