Npc316347 → Lithium Hexamethyldisilazide

HRID 1977004Notes

Reaction equation

[CH3:1][Si:2]([CH3:9])([CH3:8])[N-:3][Si:4]([CH3:7])([CH3:6])[CH3:5].C([Li:14])CCC>>[CH3:1][Si:2]([CH3:9])([CH3:8])[N-:3][Si:4]([CH3:7])([CH3:6])[CH3:5].[Li+:14]

Participants

Reactant 2

HCID 3280088Npc316347

HCID 178418339Butyllithium

Product 1

HCID 2733832Lithium Hexamethyldisilazide

Conditions

Temperature: 0 °C

Procedure

In a dry 100 mL 3-neck flask, equipped with a magnetic stirrer, was placed 5 mL of the replacement solvent to be investigated. To this was added hexamethyldisilazide (HMDS, 0.360 mL, 1.17 mmol). The mixture is cooled to 0° C. and n-butyl lithium was added in a 1:1 mole ratio. The reaction is stirred (ca. {fraction (1/2)}h) to obtain lithium hexamethyldisilazide (LHMDS).

Workup

customIn a dry 100 mL 3-neck flask, equipped with a magnetic stirrer

Sources & evidence

ORD record: ord-7ac84ee6f984442ea4ec84c7d4465798
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06231783B1

Reaction notes

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