Hydrochloric Acid → HCID 69435449, compound

HRID 1977022Notes

Reaction equation

HRID 1977022 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[F:8][C:9]1[CH:26]=[CH:25][C:12]([O:13][CH2:14][C@H:15]2[CH2:24][N:19]3[CH2:20][CH2:21][NH:22][CH2:23][C@@H:18]3[CH2:17][CH2:16]2)=[CH:11][CH:10]=1.Cl>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][C@H:15]2[CH2:24][N:19]3[CH2:20][CH2:21][N:22]([C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=4)[CH2:23][C@@H:18]3[CH2:17][CH2:16]2)=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 79732-BromopyridineHCID 53849828HCID 53849828, compound

Product 1

HCID 69435449HCID 69435449, compound

Procedure

The title compound was synthesized according to Preparation 11 using 2-bromopyridine and (7R,9aS)-7-(4-fluorophenoxy)methyl-2,3,4,6,7,8,9,9a-octahydro-1H -pyrido[1,2-a]pyrazine (Preparation 8). mp (—HCl) 261-263° C. HRMS calcd for C20H24FN3O: 341.1903; found, 341.1928.

Sources & evidence

ORD record
ord-c1a5ae7565fd41d1a0aa4fcb51d3605a
Source dataset
uspto-grants-2001_05
Patent number
US06231833B1

Reaction notes

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