Water → HCID 15405497, compound

HRID 1977087Notes

Reaction equation

HRID 1977087 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:10]2[C:14](Cl)=[C:13]([S:16]([CH3:19])(=O)=O)[N:12]([CH3:20])[N:11]=2)[C:7]=1[CH:8]=[O:9])#[N:2].[OH:21][CH2:22][CH2:23]CO.[C:26]1(C)C=CC(S(O)(=O)=O)=C[CH:27]=1.O>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:10]2[CH:14]=[C:13]([S:16][CH3:19])[N:12]([CH3:20])[N:11]=2)[C:7]=1[CH:8]([O:21][CH2:22][CH3:23])[O:9][CH2:26][CH3:27])#[N:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 104421,3-PropanediolHCID 21997415HCID 21997415, compound

Product 1

HCID 15405497HCID 15405497, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.0 g (3.2 mmol) of 4-cyano-5-formyl-1-(4-chloro-1-methyl-5-methylsulfonyl-3-pyrazolyl)pyrazole, 0.35 g (4.6 mmol) of 1,3-dihydroxypropane and 10 mg of p-toluenesulfonic acid in 40 ml of toluene are heated on a water separator for 3 hours. Work-up as in Example 1.3 gives the title compound in the form of colorless crystals.

Sources & evidence

ORD record
ord-6cb953e82eee4b90a4d1f3cf063de93e
Source dataset
uspto-grants-2001_05
Patent number
US06232271B1

Reaction notes

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