反应详情

To a solution of 3-(3-tert-butoxycarbonylaminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione (1.9 g, 4.5 mmol) in ethyl acetate (200 mL) at −78° C. was added HCl (g) for 5 min. The reaction was warmed to ambient temperature, the excess HCl removed by bubbling through nitrogen gas and then the reaction concentrated to provide the hydrochloride salt of 3-(3-aminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione as a white solid.

1. customthe excess HCl removed
2. customby bubbling through nitrogen gas
3. concentrationthe reaction concentrated