Hydrochloric Acid → 3-(3-aminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione

HRID 1977232Notes

Reaction equation

HRID 1977232 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]1[C:17](=[O:18])[C:16]([CH3:19])=[CH:15][N:14]([CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:13]1=[O:27])=O)(C)(C)C.Cl>C(OCC)(=O)C>[NH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:17](=[O:18])[C:16]([CH3:19])=[CH:15][N:14]([CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:13]1=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 155501533-(3-tert-butoxycarbonylaminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione

Product 1

HCID 155501543-(3-aminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-(3-tert-butoxycarbonylaminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione (1.9 g, 4.5 mmol) in ethyl acetate (200 mL) at −78° C. was added HCl (g) for 5 min. The reaction was warmed to ambient temperature, the excess HCl removed by bubbling through nitrogen gas and then the reaction concentrated to provide the hydrochloride salt of 3-(3-aminopropyl)-1-benzyl-5-methyl-1H-pyrimidine-2,4-dione as a white solid.

Workup

  1. customthe excess HCl removed
  2. customby bubbling through nitrogen gas
  3. concentrationthe reaction concentrated

Sources & evidence

ORD record
ord-98dc5f3ce95942eaa376455a0294d1b1
Source dataset
uspto-grants-2001_05
Patent number
US06232318B1

Reaction notes

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