Diisopropyl Ether → HCID 1674586, compound

HRID 1977267Notes

Reaction equation

HRID 1977267 reaction equation
N1(O[C:11](=[O:23])[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:14][CH:13]=2)C2C=CC=CC=2N=N1.[NH2:24][NH:25][C:26]([NH2:28])=[S:27].C(OC(C)C)(C)C>CN(C)C=O>[CH2:19]([O:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]([NH:24][NH:25][C:26]([NH2:28])=[S:27])=[O:23])=[CH:17][CH:16]=1)[CH2:20][CH2:21][CH3:22]

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 2723789ThiosemicarbazideHCID 54529397HCID 54529397, compound

Product 1

HCID 1674586HCID 1674586, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-n-butyloxybenzoic acid benzotriazol-1-yl ester (15 g) in N,N-dimethylformamide (100 ml) was added thiosemicarbazide (5.27 g) and the mixture was stirred for 12 hours at ambient temperature. The reaction mixture was pulverized with diisopropyl ether. The precipitate was collected by filtration to give 1-(4-n-butyloxybenzoyl)thiosemicarbazide (11.51 g).

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-1d7918c14f2243fa8db20225da40cdb7
Source dataset
uspto-grants-2001_05
Patent number
US06232290B1

Reaction notes

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