HCID 532661, compound → 4-(tert-Butyldimethylsiloxy)phenol

HRID 1977446Notes

Reaction equation

HRID 1977446 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[Si:16]([O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1)([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17]

Participants

4

Reactant 1

HCID 532661HCID 532661, compound

Product 1

HCID 5973884-(tert-Butyldimethylsiloxy)phenolYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1-(Benzyloxy)-4-(tert-butyldimethylsilyloxy)benzene was dissolved in ethyl acetate (400 ml) and 5 g of palladium on active carbon (5%) were added. After hydrogenation, the catalyst was removed by filtration and the solvents were removed under vacuo, to yield 42 g of 4-(tert-butyldimethylsilyloxy)-phenol (97%).

Workup

  1. customAfter hydrogenation, the catalyst was removed by filtration
  2. customthe solvents were removed under vacuo

Sources & evidence

ORD record
ord-35f7b3dc1a6b4e46a27f68465bd3f854
Source dataset
uspto-grants-2001_05
Patent number
US06232430B1

Reaction notes

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