Acetanilide → HCID 16640263, compound

HRID 1977656Notes

Reaction equation

HRID 1977656 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].Br[C:12]1[CH:16]=[CH:15][S:14][CH:13]=1>>[S:14]1[CH:15]=[CH:16][C:12]([N:4]([C:1](=[O:3])[CH3:2])[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)=[CH:13]1

Participants

3

Reactant 2

HCID 904AcetanilideHCID 133833-Bromothiophene

Product 1

HCID 16640263HCID 16640263, compoundYield 25.2%

Procedure

Using acetanilide (6.0 g) and 3-bromothiophene (14.5 g), a reaction was made in the same manner as in 1) of Production Example 2. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:4) produced N-(3-thienyl)acetanilide (2.43 g; yield, 25%) as a pale brown solid.

Workup

  1. customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:4)

Sources & evidence

ORD record
ord-dee149cd1efa46b79296b1ee29f3b32f
Source dataset
uspto-grants-2001_05
Patent number
US06235730B1

Reaction notes

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